Following the administration of NaHS, however, TNF-α, IL-1β and IL-6 levels in the serum and myocardial tissues of rats, as well as ICAM-1 mRNA expression in myocardial tissues and NF-κB protein expression, were decreased, indicating that exogenously supplemented H2S inhibited the synthesis of inflammatory cytokines (such as IL-1β), nuclear transcription factors (such as TNF-α) and adhesion molecules in the serum and myocardial tissues of rats following the development of myocardial ischemia, thereby reducing myocardial injury and protecting myocardial tissues. Here, IL6 is linked to myocardial ischemia.