HIF1A and central nervous system cancer: The 3-(5-hydroxymethyl-2-furyl)-1-benzylindazole (YC-1)-induced inhibition of HIF-1α has been found to downregulate the VM formation of glioma cells (9) under hypoxic conditions; other pathways, aside from the HIF-1α pathway, may also affect the VM formation of glioma cells (10–12).