Cai et al (10) observed that the cytokines interleukin (IL)-6, -8, and -10, interferon-γ-inducible protein 10, tumor necrosis factor (TNF)-α, soluble TNF receptor 1 (STNFR1) and STNFR2 in BALF were significantly increased in COP patients, and macrolides significantly decreased their levels. The gene discussed is TNF; the disease is cryptogenic organizing pneumonia.