In myeloma cells, the expression of the pro (BH3-only, Bax, Bak) and anti-apoptotic (Bcl2, Mcl1) molecules of the Bcl2 family is different according to the molecular classification of patients with multiple myeloma, as shown by Drs. Gomez-Bougie and Amiot, who conclude that the apoptosis threshold in myeloma differs greatly between subsets of patients (8). The gene discussed is BAK1; the disease is plasma cell myeloma.