KCNJ13 and Leber congenital amaurosis: Although it will be necessary to generate a conditional knockout mouse model to fully investigate the detailed mechanism of Kcnj13-associated photoreceptor degeneration, the Kcnj13 F0 mosaics reported here have allowed us to rapidly test if the mouse will provide a good model for studying KCNJ13-associated LCA disease phenotypes.