Curcumin significantly increased the cytotoxicity of erlotinib -resistant H1975 and H1650 NSCLC cells, and enhanced erlotinib-induced apoptosis, down-regulated the expression of EGFR, p-EGFR, and survivin in erlotinib-resistant NSCLC cells [210]. This evidence concerns the gene BIRC5 and non-small cell lung carcinoma.