In yet another study using androgen-independent prostate cancer cells, curcumin was found to decrease the level of Tcf-4, CBP, and p300 proteins that are implicated in the Wnt transcriptional complex, leading to the decrease of ß-catenin/Tcf-4 transcriptional activity and of the expression of β-catenin target genes (cyclin D1 and c-myc) [169]. Here, TCF4 is linked to Familial prostate cancer.