In multidrug-resistant breast cancer model, MCF-7 and MCF-7R (which lacks estrogen receptor alpha [ERα] and overexpresses p-glycoprotein, different IAPs ([inhibitor of apoptosis proteins] and COX-2, curcumin inhibited cell proliferation and induced apoptosis, and the effect was more potent in the multidrug-resistant MCF-7R compared to its parental MCF7 cells [144]. Here, ESR1 is linked to breast cancer.