TP53 and neoplasm: Curcumin also enhanced expression of p53 molecule in tumor tissue, and modulated the apoptotic pathway in colorectal cancer cells [233], ovarian cancer [234], cisplatin-resistant ovarian cancer [235] and induced the expression of FOXO3a and p53 in nasopharyngeal carcinoma [236] by serine phosphorylation of p53 in a concentration- and time-dependent manner.