In the HTLV-I-transformed T cell leukemia lines, MT-2, HuT-102, and SLB-1, which express constitutively phosphorylated JAK2, TYK2, STAT3, and STAT5 signaling proteins, curcumin induced a dose-dependent decrease in JAK and STAT phosphorylation, resulting in the induction of growth-arrest and apoptosis in T cell leukemia [141]. The gene discussed is JAK2; the disease is T-cell leukemia.