Curcumin significantly inhibited proliferation in Eker rat-derived uterine leiomyoma cell lines (ELT-3) via activation of PPARγ, where curcumin acted as a PPARγ ligand and, in the presence of a PPARγ antagonist, the inhibitory effect of curcumin was reversed [125]. The gene discussed is PPARG; the disease is uterine corpus leiomyoma.