SCRIB and cancer: Alteration of SCRIB localization at the membrane often mimics SCRIB loss-of-function phenotype (Zhan et al., 2008; Cordenonsi et al., 2011; Elsum and Humbert, 2013) and SCRIB aberrant accumulation in the cytosol strongly correlates with poor survival in human cancers (Nakagawa et al., 2004; Navarro et al., 2005; Gardiol et al., 2006; Kamei et al., 2007; Ouyang et al., 2010; Pearson et al., 2011; Feigin et al., 2014).