TMPRSS11D and neuroblastoma: Importantly, both the pan-HAT inhibitors PU139 and the KAT3-selective inhibitor PU141 exhibited a significant antitumor effects against neuroblastoma xenografts in vivo. In addition, PU139 was shown to synergize with doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition in vivo.