With increasing family history risk category of diabetes, the levels of previous maximal weight, prevalence of central obesity, present BMI, systolic and diastolic blood pressure, fasting glucose and insulin, 2-h postloading glucose and insulin levels, total serum cholesterol levels, triglyceride levels, and low-density lipoprotein cholesterol levels all showed a significantly increasing trends (Table 1). The gene discussed is INS; the disease is Abdominal obesity.