There were no significant differences between the three groups for SHP (Fig. 3D), while, the T2D-R group had signifciantly lower expression levels for HNF4α (Fig. 3B), GS (Fig. 3F), and FXR (Fig. 3H), compared to No-T2D and T2D-NoR. This evidence concerns the gene NR0B2 and type 2 diabetes mellitus.