In addition, CYP7A1 and β-Klotho mRNA levels were higher in T2D patients, confirming past data [10], and further underscoring the presence of dysregulation in enterohepatic signaling involving the FGF19-CYP7A1-BA pathway and FGF21 production in diabetic patients. This evidence concerns the gene FGF21 and type 2 diabetes mellitus.