The additional analyses in which this SNP, rs769449, and/or rs7412 in APOE were removed from the GRS for Alzheimer's disease suggest that additional Alzheimer's disease-associated genetic variants appear to be less frequent in the older generation of LLFS participants while generally, for other age-related diseases, such a relative lack of disease associated variants amongst exceptional survivors does not seem to be the case. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.