IRF3 and steatosis: As an example, the whole-body interferon regulatory factor 3 knockout (IRF3-KO) mice were protected from alcohol-induced liver injury, steatosis, and inflammation, while in wild-type or bone marrow-specific IRF3-KO mice, deficiency of IRF3 only in parenchymal cells aggravated alcohol-induced liver injury and was associated with increased pro-inflammatory cytokines, lower anti-inflammatory cytokine interleukin 10 (IL-10), and lower Type I IFNs compared to wild-type mice [86].