To this end, NS5A inhibits the expression of numerous genes encoding for molecules involved in TLR4 signaling (CD14, MD-2, myeloid differentiation primary response gene 88, IRF3, and NF-κB), thereby disrupting LPS-induced TLR4-mediated apoptosis in human hepatocytes [62], which finally affects HCV-infection pathogenesis. The gene discussed is TLR4; the disease is infection.