In addition, Rocatello et al (Menegattia et al. 2009) showed that polymorphisms in uteroglobin (a multifunctional protein with anti-inflammatory properties) and NF-κB2 (a transcription factors that regulates the expression of a wide range of immune response genes) were associated with a genetic predisposition towards developing both vasculitis and RA. This evidence concerns the gene SCGB1A1 and rheumatoid arthritis.