PLAT and stroke disorder: Based on the results of the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Registry (SITS-ISTR) [11] and the European Cooperative Acute Stroke Study III (ECAS III) [12], the time window of IV-tPA was extended from 3 hours to 4.5 hours after the onset of stroke symptoms in Japan in 2012, and in cases with indications for t-PA treatment the time window may be even greater.