BIN1 and autosomal dominant centronuclear myopathy: Mutations in the PTPLA gene have not been reported to date in human cases of CNM, however, mutation in the BIN1 exon 11 acceptor splice site was recently shown to be the cause of a rapidly progressive and fatal centronuclear myopathy in both a consanguineous human family and in young Great Dane dogs with a progressive CNM [14].