More importantly, we have demonstrated that SLs and their derivatives were able to significantly decrease AOPP-induced MCP-1 expression in podocytes by inhibiting the IKK/NF-κB pathway, suggesting that SLs may protect against DN as well as other inflammatory and immune renal diseases mainly through NF-κB inhibition and anti-inflammatory effects. The gene discussed is NFKB1; the disease is liver dysplastic nodule.