BECN1 and cancer: BimEL and BimL appear to inhibit autophagy by sequestering Beclin-1 (33); in the present study, a simultaneous, dose-dependent increase in BimL and decrease in Beclin-1 was observed in the BJOE-treated HCT116 cancer cells, indicating that BimL may be important in the association between BJOE-mediated apoptosis induction and autophagy inhibition.