ERBB2 and inflammatory breast carcinoma: The neo-adjuvant Herceptin study (16), in which patients with HER2-positive locally advanced or inflammatory breast cancer were randomly allocated to the chemotherapy or chemotherapy plus trastuzumab groups, demonstrated a doubling in the pCR rate in the trastuzumab group compared with the chemotherapy group, and a strong correlation between the pCR rate and event-free survival was also identified.