CDK1 and non-small cell lung carcinoma: In addition, the prognostic role of Cdk1 in advanced NSCLC was validated by combining the expression levels of dephospho- and phospho-Cdk1; Cox regression analysis of this variant (active Cdk1) determined that active Cdk1 expression (OR, 0.624; 95% CI, 0.400–0.973; P=0.038) was also an independent prognostic factor of NSCLC (Table II).