Finally, Spearman’s correlation analysis revealed that the poor survival of upregulated CD14+HLA-DRlow/−MDSC CLL patients predominantly occurred via the inhibition of the CD4+ T-cell response, resulting in a dysregulation of the balance of T-cell subsets in vivo, including significant proliferation of CD5+CD19+ cells in CLL patients. This evidence concerns the gene CD5 and B-cell chronic lymphocytic leukemia.