SERPINE1 and metabolic syndrome: In addition, insulin resistance inhibits nitric oxide (NO) synthesis in vascular endothelial cells (4), promotes the secretion of inflammatory mediators, such as tumor necrosis factor, plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6), C-reactive protein (CRP) and free fatty acid (5,6), and ultimately results in an abnormal blood glucose concentration and dyslipidemia.