In human papillomavirus (HPV) infected cervical carcinoma, the HPV virus produces E6 and E7 proteins (7) that inactivate cyclin-dependent kinase inhibitors (CKI), including P16INK4A and retinoblastoma protein (Rb), or cause the overexpression of cyclin D that releases active E2F, which induces cell cycle traversal (8). The gene discussed is RB1; the disease is cervical carcinoma.