RB1 and cervical carcinoma: The tumor suppressor and CKI, P16INK4A, which is usually overexpressed in cervical carcinoma, is not detectable in cervical carcinomas, which are predominantly sensitive to DDP (12,13), and the cyclin D-CDK4,6/p16/phosphorylated RB (pRb)/E2F cascade is altered in >80% of human tumors (14–17).