PTEN and colorectal carcinoma: The tumor suppressor phosphatase and tensin homolog (PTEN) is significantly correlated with CRC (45), and its pseudogene, PTENP1 (also known as PTENpg1), can parallel PTEN and play a growth-suppressive role in CRC cells, although the PTENP1 locus is selectively lost in CRC (46,47).