IGF2 and colorectal carcinoma: Although the hypermethylation of a differentially-methylated region (DMR) upstream of the H19 gene may result in activation of the normally silent maternal allele of the insulin-like growth factor-II gene (IGF2) (9), hypomethylation of the H19 DMR and a DMR upstream of IGF2, is observed in the CRC and normal mucosa of a single patient (10).