TRAIL exerts antitumor effects by inducing tumor cell apoptosis, IL-10 exerts antitumor effects through its anti-inflammatory action and IL-12 exerts antitumor effects by activating CTLs and natural killer (NK) cells and through the expression of cytotoxic mediators, which can lead to tumor suppression (50). This evidence concerns the gene TNFSF10 and neoplasm.