NPM1 and endometrium adenocarcinoma: To investigate if there is a possible hormonal regulation of NPM1 expression, we quantified NPM1 expression levels in primary-cultured FIGO stages I endometrial adenocarcinoma cells stimulated with estrogen (E2 0, 0.1, 0.5, 1, 5 μm/ml) for 24 h using qRT-PCR and Western blotting.