To select an optimal PTPN12 cutoff score for further analysis, the ROC curves for each clinicopathological feature (Fig. 2) show the arrow on the curve closest to the point (1.0, 0.0), which maximizes both the sensitivity and specificity for the outcome [17, 19], cancers with score above the obtained cutoff value were considered as normally expressed PTPN12, which led to the greatest number of cancers classified as having or not having the clinical outcome. The gene discussed is PTPN12; the disease is cancer.