Nevertheless, the underlying mechanism by which PTPN12 affects prognosis remains unclear and will require further investigation, Therefore, we will deeply study the mechanisms underlying PTPN12 association gene-mediated progression and metastasis of NPC in future experiments, by identifying the receptor, adapters, target proteins, and pathways of the abovementioned gene. This evidence concerns the gene PTPN12 and nasopharyngeal carcinoma.