As our panel of melanomas has previously been analyzed for regulators of the cell cycle (Ki-67, Cyclin A, D1, D3, p21CIP1/WAF1, p27Kip1 and p53) 23–27 and activation of signaling pathways (AKT, MAPK, p38, JNK) 28,29 we examined the relationship between CIP2A and these factors. This evidence concerns the gene MAPK8 and melanoma.