To further elucidate the role of CIP2A we transiently downregulated the protein in four melanoma cell lines harboring the common genetic mutations BRAFV600E (WM983b), BRAFV600E/PTENnull (WM9), NRASQ61K (1366) and the less frequently seen HRAS mutation (FEMX1). Here, CIP2A is linked to melanoma.