As our panel of melanomas has previously been analyzed for regulators of the cell cycle (Ki-67, Cyclin A, D1, D3, p21CIP1/WAF1, p27Kip1 and p53) 23–27 and activation of signaling pathways (AKT, MAPK, p38, JNK) 28,29 we examined the relationship between CIP2A and these factors. The gene discussed is MKI67; the disease is melanoma.