Another study has shown that miR-494 can downregulate PTEN gene expression in cells transformed by anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide(Liu et al. 2010), indicating that miR-494 may be downregulated the expression of PTEN gene to promote the progression of gliomas. The gene discussed is PTEN; the disease is glioma.