TRPM8 and migraine disorder: Single nucleotide polymorphs (SNPs) within the TRPM8 gene have consistently been found to show a protective association with migraine in multiple studies as well as in a meta-analysis of all migraine GWAS suggesting that TRPM8 modulators may act as migraine therapeutics (Chasman et al. 2011; Schurks 2011; Freilinger et al. 2012; Anttila et al. 2013; Esserlind et al. 2013; Chasman et al. 2014).