TRPM8 and migraine disorder: Besides interest in TRPM8 as a temperature sensor and target for migraine, it has also been considered as a potential target for chronic pain based on results in KO mice, receptor expression, and early pharmacology (Daniels and McKemy 2007; Stucky et al. 2009; Liu and Qin 2011; Malkia et al. 2011; McCoy et al. 2011; Almaraz et al. 2014).