Both of these normal groups have breeding records that indicate freedom or low risk of ARVC, the defined-by-ancestry group has served as an effective control in a GWAS study (R M Hamilton, personal communication), and finally both groups are indicated to be effectively ARVC free by the fact that selective breeding into this population, which carries the STRN mutation in high frequency, has virtually eliminated ARVC from the show section of the UK Boxer population. This evidence concerns the gene STRN and Arrhythmogenic right ventricular dysplasia.