In this study, based on immunofluorescence methods including double labelling for CD34 and c-kit/CD117, or vimentin, or PDGF Receptor-α, or β, we showed that in human liver fibrosis, hepatic TCs were significantly decreased, suggesting that loss of TCs might lead to the altered organization of extracellular matrix and loss the control of fibroblast/myofibroblast activity and favour the genesis of fibrosis. Here, CD34 is linked to Hepatic fibrosis.