MBTPS1 and cardiovascular disorder: Sphingosylphosphorylcholine (SPC) is derived from membrane sphingomyelin and is present in the plasma in submicromolar-free concentrations and as a major component of low- and high-density lipoproteins; it is also released from activated platelets.1–3 Sphingolipids including SPC and sphingosine-1-phosphate (S1P) have been associated with cardiovascular disease, but whereas S1P has been extensively investigated and its receptors cloned, no specific receptor for SPC has been positively identified and there are no selective pharmacological antagonists.