GLI1 and neoplasm: 270). Glabrescione B is an isoflavone naturally present in the seeds of Derris glabrescens. Remarkably, as consequence of its strong inhibition of Gli1 activity, Glabrescione B inhibits growth of Hh-dependent BCC and MB tumour cells in vitro and in vivo as well as self-renewal ability and clonogenicity of CSCs (Ref. 270).