NOS2 and obesity due to melanocortin 4 receptor deficiency: In particular, fucoxanthin, astaxanthin, lycopene, and lutein are strong FRs, quenchers of ROS, and NOS, so that their antioxidant and antinflammatory activity may help against cardiovascular risk factors such as markers of inflammation, hyperlipidemia, hypertension, insulin resistance, and obesity.