HACE1 and cancer: Previous studies have provided evidence that HACE1 is lost in multiple cancer types due to allelic loss or promoter methylation.10, 11, 12, 13 In addition, HACE1 knockout mice have been shown to develop spontaneous tumors at multiple locations, including the breast, after a prolonged latency period.13HACE1 expression was analyzed in multiple clinical patient data sets including The Cancer Genome Atlas (TCGA) breast data set.