In this study, HLA-B*07:05 was associated with a reduced risk of developing severe dengue (DHF/DSS), HLA-B alleles 38:02 and 58:01 were associated with a reduced risk of developing both severe dengue (DHF/DSS) and DSS, and HLA-B*48:01 was reduced in the DF compared to the background population group. The gene discussed is HLA-B; the disease is dengue disease.