When CD4+ cells from 5 TB patients and 5 donors with LTBI+ were cultured with autologous monocytes and γ-irradiated M. tb for 4 days, the percentages of CD4+CD25+Foxp3+D4GDI+ cells were higher in persons with LTBI+ (p = 0.0004, Fig. 10C) compared to TB patients, suggesting reduced expansion of D4GDI+ cells in TB patients. Here, CD4 is linked to tuberculosis.