FLG and psoriasis: On the other hand, OSM was linked to the pathology of psoriasis through its ability to inhibit expression of keratinocyte differentiation markers, including filaggrin and loricrin, which are decreased in the skin of psoriatic patients, or through inducing AMPs in reconstituted epidermis, such as psoriasin (S100A7), calgranulin C (S100A12) and β-defensin 2, which are strongly associated with psoriasis [38,43,52].