In T98G cells (a human glioma cell line), FHL3-induced apoptosis was mediated by caspase3 and Ang took part in the regulation of evolution process of astrocytoma by mediating NF-κB pathway, so we hypothesized that Ang may activate NF-κB pathway by regulating the expression of FHL3 [21]. The gene discussed is NFKB1; the disease is central nervous system cancer.