RORC and Alzheimer disease: Simultaneously, expression levels of T-bet and ROR-γ, the specific transcription factors associated with proinflammatory Th1 and Th17 cells, respectively, were upregulated, whereas expression levels of GATA-3 and Foxp3, the specific transcription factors associated with antiinflammatory Th2 and Treg cells, respectively, were downregulated in the hippocampus of AD model rats (Fig. 5B).