SMAD2 and kidney disorder: ,A number of anti-fibrotic agents, including Norcantharidin [31], Cordyceps sinensis[32], IL-7[33], proteasome inhibitor(MG132 and lactacystin) [34], mycophe[35] and PXS25 [22] have been shown to inhibit the TGFβ1-induced Smad2 pathway in both animal models of renal disease and in cultured tubular cells.