Pairwise comparisons showed significant differences between the SCZ group and the MDD, BD and control groups (p = 1.8×10−7, p = 1.0×10−5 and p = 2.7×10−8, respectively), indicating that EGR1 mRNA level was upregulated in SCZ fibroblasts relative to all the other groups (Fig. 2A). The gene discussed is EGR1; the disease is major depressive disorder.