Characterization of the T-bet+ Th1-Treg cell population from mice with DC-specific IL-6 deletion or with Treg cell-specific IL-6R (IL-6 receptor) ablation should provide further insights into the potential involvement of IL-6 signaling in Th1-Treg cell-mediated regulation of Th1 immunity particularly in an infection setting. Here, IL6R is linked to infection.