Consistent with our observation in uninfected mice, despite having similar frequencies of total Foxp3+ Treg cells (S5A Fig. in S1 Text), infected CD11ccreIFNγR2fl/fl mice harbored significant reduced T-bet+ Treg cells compared to their WT counterparts in the Lamina Propria (LP) of the small intestine 4 days after infection (S5B Fig. in S1 Text). The gene discussed is FOXP3; the disease is infection.