On the contrary, AD skins showed over-expressed CYP11A1 proteins, while BSYQ (6g/kg, 13g/kg and 26g/kg) treatment markedly down-regulated the expression of CYP11A1 in the skin lesions (P<0.01 for three, Fig. 5 below). This evidence concerns the gene CYP11A1 and Alzheimer disease.