CRHR1 and Alzheimer disease: BSYQ treatment dose-dependently increased CRHR1 mRNA expressions in the AD lesion skin and the BSYQ 26g/kg treatment group reached at the peak level (p<0.05).The expressions of CRHR2 and NR3C1 were down-regulated in AD mice (p<0.05 for both), while, BSYQ did not display obvious effects on both of them.