As compared with blank control group, the concentrations of ACTH and corticosterone significantly reduced in the AD group, however, BSYQ (13g/kg, 26g/kg) treatment significantly increased the levels of ACTH (p<0.05 p<0.01) and corticosterone(p<0.05) in serum of AD mice (Fig. 4F and Fig. 4G). This evidence concerns the gene POMC and Alzheimer disease.