In this study, we found that the expression of skin HPA axis elements, POMC and CYP11A1, in AD mice were higher than that of control group, while the CRH, NR3C1 and CYP11B1 mRNA were significantly down-regulated and the receptors of ACTH, MC2R, were slightly down-regulated. This evidence concerns the gene CYP11B1 and Alzheimer disease.