In addition, previous workby Bao et al. [21] demonstrated that c-Src prevents c-Cbl mediated endocytosis andubiquitination of EGFR, thereby prolonging its signaling at the cell surface.Overall, EGFR and c-Src synergize to promote tumour growth and progression [20,22], and as a result, thesedeleterious interactions between the two kinases represent an appropriatemulti-signaling context to challenge the new type III combi-targeting model. This evidence concerns the gene EGFR and neoplasm.