Compared to CON, HF-S increased Srebf1 and Insig1 mRNAs (effect of diet: P≤0.02), irrespective of muscle fiber type, and increased Dgat1 and decreased Scd1 mRNA in the soleus muscle alone (diet*muscle interaction: P≤0.05; P≤0.005). The gene discussed is INSIG1; the disease is hydrops fetalis.