PPARGC1A and hydrops fetalis: The increase in Pgc1 α mRNA and prevention of HF-S-induced Ppar α suppression by HF-FO is consistent with beliefs that n-3 PUFAs are natural PPAR α agonists and that n-3 PUFAs, via PPAR α, exert triacylglycerol-lowering effects directing fat away from storage into oxidation [60].