However, in past, HF-FO in female Wistar rats completely prevented [52] (47% E fat lard-diet vs equi-caloric diet 7% lard replaced with marine oil), and in humans partially ameliorated (75% fat vs equi-caloric diet 15% fat replaced with n-3 PUFA), induction of PDK4 activity [53]. This evidence concerns the gene PDK4 and hydrops fetalis.