Compared to CON, HF-S decreased Pgc1α mRNA in the soleus muscle (diet*muscle interaction: P≤0.001) and Pparα mRNA in both muscles (effect of diet P≤0.05) and increased Ampkα2 mRNA irrespective of muscle fiber type (effect of diet P≤0.05). The gene discussed is PRKAA2; the disease is hydrops fetalis.