mRNA expression of VEGFR-2, ICAM-1, E-selectin, VCAM-1, and Cdh5 were significantly decreased in ob/ob (Lep KO) and db/db (Lepr KO) mice as compared to DIO +BDCM group mice that had NASH (Fig. 4A) (P<0.05). The gene discussed is LEPR; the disease is metabolic dysfunction-associated steatohepatitis.