Results showed that protein expression of VEGFR-2, ICAM-1 and E-selectin, measured by the immunoreactivity of these markers in liver slices were significantly decreased in miR21 knockout mice as compared to DIO mice co-exposed to high fat and BDCM for NASH induction at 1w post initiation of toxin administration (Fig 6A). Here, SELE is linked to metabolic dysfunction-associated steatohepatitis.