While CD11b- cells as well as SKOV3ip1 cells produced little IL-6 (CD11b-; 0.21 ± 0.19 ng/1x105 cells, SKOV3ip1; 0.0048 ± 0.0009 ng/1x105 cells), CD11b+CD14+ cells produced a high level of IL-6 compared with CD11b+CD14- or other cells (CD11b+CD14+; 9.86 ± 4.78 ng/1x105 cells, CD11b+CD14-; 2.91 ± 1.70 ng/1x105 cells) (Fig. 5B), suggesting that IL-6 in ovarian cancer ascites is mainly produced from macrophages. This evidence concerns the gene ITGAM and ovarian carcinoma.