In case of non-HAART Pediatric HIV patients, E. histolytica/dispar [AOR, 95%CI: 9.33(1, 50), P<0.05], Hookworm [AOR, 95%CI: 9(1.7, 50), P<0.05], and Taenia species [AOR, 95%CI: 14(1, 175), P<0.05] were non opportunistic IPs significantly associated with CD4+ T cell levels < 350 cells/μL in this study. The gene discussed is CD4; the disease is ichthyosis prematurity syndrome.