The androgen receptor was the second most significant upstream regulator with multiple downstream genes on the gene list, namely, fibroblast growth factor 10 (FGFR10), integrin, alpha 6 (ITGA6), CLDN11, nerve growth factor receptor (NGFR), NKX3-1, MSMB, and KLK3. The transcription regulator prefoldin-like chaperone (URI1) also regulates the expression of the AR, as well as a shared downstream gene on the gene list, such as NKX3-1 [16], a tumor suppressor commonly deleted in prostate tumors. Here, KLK3 is linked to prostate neoplasm.